Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning
نویسندگان
چکیده
منابع مشابه
Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpain.
Exercise provides protection against myocardial ischemia-reperfusion (IR) injury. Understanding the mechanisms of this protection may lead to new interventions for the prevention and/or treatment of heart disease. Although presently these mechanisms are not well understood, reports suggest that manganese superoxide dismutase (MnSOD) and calpain may be critical mediators of this protection. We h...
متن کاملLate Preconditioning against Myocardial Stunning
Introduction Conscious pigs underwent a sequence of 10 2-min coronary occlusions, each separated by 2 min of reperfusion, for three consecutive days (days 1, 2, and 3 of stage I). The recovery of systolic wall thickening (WTh) after the 10th reperfusion was markedly improved on days 2 and 3 compared with day 1, indicating that the myocardium had become preconditioned against "stunning." 10 d af...
متن کاملProtein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning.
Although protein tyrosine kinases (PTKs) signaling has been implicated in the late phase of ischemic preconditioning (PC), it is unknown whether PTK signaling is necessary for the development of nitric oxide (NO) donor-induced late PC. Thus conscious rabbits underwent a sequence of six 4-min coronary occlusion (O)/4-min reperfusion (R) cycles followed by a 5-h recovery period of reperfusion for...
متن کاملLate preconditioning against myocardial stunning. Does aspirin close the "second window" of endogenous cardioprotection?
“Preconditioning with ischemia” (PC) is the phenomenon whereby one or more episodes of brief ischemia paradoxically renders the myocardium resistant to a later, more sustained ischemic insult (1–3). The cardioprotection afforded by brief, transient ischemia is biphasic; a “first window” of protection is manifest within the initial 5 min to approximately 3 h of the PC stimulus, the hallmark of w...
متن کاملPreconditioning does not attenuate myocardial stunning.
BACKGROUND Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardi...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2004
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.01208.2003